915599

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average M_n 2,000, PCL average M_n 5,000

• Synonym(s): Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL
• Linear Formula: C₃H₅O₃[C₂H₄O]_n[C₆H₁₀O₂]_mH
• UNSPSC Code: 12352106

Properties

• form: powder or chunks
• Quality Level: 100
• mol wt: PCL average M_n 5,000 (by NMR); PCL average M_n 5,000; PEG average M_n 2,000 (by NMR); PEG average M_n 2,000
• color: white to beige
• PDI: ≤1.3 (by GPC)
• storage temp.: −20°C
• SMILES string: [H]OCCCCCC(OCCOCCC(O)=O)=O

Description

Application

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable