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Key Documents

808865

Sigma-Aldrich

Gold nanoparticles

40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O

Synonym(s):

Biotin Gold

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About This Item

UNSPSC Code:
12141717
NACRES:
NA.23

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

composition

, 3.58E12 particles/mL

packaging

pkg of 0.5 mL

storage condition

do not freeze

concentration

2.33 mg/mL in H2O

OD

50

surface area

7.74 m2/g

diameter

40 nm

pH

5-7

density

1.00 g/cm3

peak SPR wavelength

530 nm

functional group

biotin

storage temp.

2-8°C

InChI

1S/Au

InChI key

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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General description

Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.

Application

Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 40 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.

Legal Information

Product of CytoDiagnostics, Inc.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
Aslan K, et al.
The Journal of Physical Chemistry B, 108(40), 15631-15639 (2004)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
Itani R, et al.
Theranostics, 10(13), 5932-5932 (2020)
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)

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