474789

(S)-(−)-Glycidol

97%, optical purity ee: 98% (GLC)

• Synonym(s): (S)-(−)-2,3-Epoxy-1-propanol, (S)-(−)-Oxirane-2-methanol
• Empirical Formula (Hill Notation): C₃H₆O₂
• CAS Number: 60456-23-7
• Molecular Weight: 74.08
• Beilstein: 79783
• MDL number: MFCD00074874
• UNSPSC Code: 12352005
• PubChem Substance ID: 24871051
• NACRES: NA.22

Properties

• Assay: 97%
• optical activity: [α]20/D −15°, neat
• optical purity: ee: 98% (GLC)
• refractive index: n20/D 1.433 (lit.)
• bp: 66-67 °C/19 mmHg (lit.)
• density: 1.116 g/mL at 20 °C (lit.)
• storage temp.: −20°C
• SMILES string: OC[C@H]1CO1
• InChI: 1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2/t3-/m0/s1
• InChI key: CTKINSOISVBQLD-VKHMYHEASA-N

Description

General description

Glycidol or 2,3-epoxy-1-propanol is a highly reactive epoxy derivative, which is generally used as a monomer in the preparation of many polymers like polyesters, polycarbonates, polyurethanes, and polyamides. It is also used in the preparation of detergents, rubbers, perfumes, fabric dyes, varnishes, cosmetics, and paints.

Application

Employed in the synthesis of chiral (E)-allylic alcohol side-chains for introduction into prostacyclin and prostaglandin frameworks by cross-metathesis.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302 + H312,H315,H319,H330,H335,H341,H350,H360F
• Precautionary Statements: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 161.6 °F
• Flash Point(C): 72 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves