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14050

Sigma-Aldrich

Berberine chloride hydrate

technical, ≥90% (AT)

Synonym(s):

Natural Yellow 18

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About This Item

Empirical Formula (Hill Notation):
C20H18ClNO4 · xH2O
CAS Number:
141433-60-5
Molecular Weight:
371.81 (anhydrous basis)
Colour Index Number:
75160
EC Number:
211-195-9
MDL number:
MFCD00011939
UNSPSC Code:
12352103
PubChem Substance ID:
57647132
NACRES:
NA.22

grade

technical

Assay

≥90% (AT)

form

powder

mp

204-206 °C (dec.)

SMILES string

[Cl-].COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChI key

VKJGBAJNNALVAV-UHFFFAOYSA-M

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lamyae El Khalki et al.
Molecules (Basel, Switzerland), 25(3) (2020-01-30)
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Non-available targeted therapy for TNBC represents its biggest treatment challenge. Thus, finding new promising effective drugs is urgently needed. In the present study, we investigated how berberine, a natural
Fatma Gizem Avci et al.
Fitoterapia, 139, 104371-104371 (2019-10-20)
Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with efflux pump inhibitors may help to restore the activities of such drugs.
Cemile Selin Aksoy et al.
Microbial pathogenesis, 149, 104542-104542 (2020-10-04)
A plethora of natural products emerges as attractive molecules in the struggle against antibiotic resistance. These molecules impose their bioactivities not only alone but also in combinations as well, which further enhances their effects. Berberine is a well-known isoquinoline alkaloid
Victor P Bagla et al.
BMC complementary and alternative medicine, 14, 383-383 (2014-10-09)
Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to
Li Jia et al.
Mediators of inflammation, 2020, 9419085-9419085 (2020-10-17)
Berberine (BER), a natural isoquinoline alkaloid, has been demonstrated to have appreciable anticolitis effects. Nevertheless, the protective mechanism of BER in ulcerative colitis (UC) is barely understood. The present study was aimed at exploring the therapeutic efficacy of BER on
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