Z226181

Nucleosil^® C18 HPLC Column

5 μm particle size, L × I.D. 25 cm × 4.6 mm

• Synonym(s): Nucleosil C18
• UNSPSC Code: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Properties

• Agency: suitable for USP L1
• product line: Nucleosil^®
• feature: endcapped
• manufacturer/tradename: Nucleosil^®
• extent of labeling: 15% Carbon loading
• parameter: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• technique(s): HPLC: suitable
• L × I.D.: 25 cm × 4.6 mm
• surface area: 350 m²/g
• matrix: octadecyl
• matrix active group: C18 (octadecyl) phase
• particle size: 5 μm
• pore size: 100 Å
• separation technique: reversed phase

Description

Application

• A combined qualitative and quantitative method development and validation of vancomycin hydrochloride injection formulation by HPLC and UV involving quality by design.: This study by Sasikala et al. developed and validated an HPLC method using a Nucleosil^® C18 column for the qualitative and quantitative analysis of vancomycin hydrochloride in injection formulations. The method demonstrated high precision and accuracy, making it suitable for quality control in pharmaceutical analysis (Sasikala et al., 2023).


• Quantification and Validation of Stability-Indicating RP-HPLC Method for Efavirenz in Bulk and Tablet Dosage Form using Quality by Design (QbD): A Shifting Paradigm.: Gurumukhi and Bari developed a stability-indicating HPLC method for quantifying efavirenz in bulk and tablet forms, using a Nucleosil^® C18 column. The study highlighted the method′s robustness and reliability, essential for ensuring the stability and efficacy of pharmaceutical products (Gurumukhi et al., 2022).


• Purification and Product Characterization of Lipoxygenase from Opium Poppy Cultures (Papaver somniferum L.).: Holková et al. utilized a Nucleosil^® C18 column in their HPLC method to purify and characterize lipoxygenase from opium poppy cultures. The research demonstrated the column′s effectiveness in isolating and analyzing plant-derived enzymes, contributing to biochemical and pharmacological studies (Holková et al., 2019).


• Fabrication of size controlled nanocomposite based on zirconium alkoxide for enrichment of Gallic acid in biological and herbal tea samples.: Bahrani et al. developed a nanocomposite for enriching gallic acid, employing a Nucleosil^® C18 column in their HPLC method to analyze biological and herbal tea samples. The study underscored the column′s role in enhancing analytical precision in complex matrices (Bahrani et al., 2018).

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Nucleosil^® C18 HPLC Columns are packed with the finest commercially available silicas and bonded phases from the most recognized HPLC manufacturers in the world. The columns are tested with specially selected solutes that can be used to establish the reproducibility of retention and selectivity needed in the HPLC applications.

Legal Information

Nucleosil is a registered trademark of Macherey-Nagel GmbH & Co. KG