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SRP8030

Sigma-Aldrich

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Synonym(s):

CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~35 kDa by SDS-PAGE

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

General description

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water.

Other Notes

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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