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Key Documents

SAB5300461

Sigma-Aldrich

Monoclonal Anti-FOXP3 antibody produced in mouse

clone 2A11G9, ascites fluid

Synonym(s):

AIID, IPEX, JM2, PIDX, XPID

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2A11G9, monoclonal

species reactivity

mouse, human

technique(s)

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG1

NCBI accession no.

NM_014009

UniProt accession no.

Q9BZS1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... Foxp3(50943)

General description

Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4+CD25+ regulatory T-cell subsets.

Immunogen

Purified recombinant fragment of human Foxp3 expressed in E.coli.
Mouse monoclonal antibody raised against Foxp3

Application

Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).

Biochem/physiol Actions

Forkhead box P3 (FOXP3) plays an essential role in the development of CD4+CD25+ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion
Hou Wenhui, et al.
Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology, 42(11), 1439-1444 (2016)
FOXP3 gene variations and susceptibility to autism: a case-control study
Safari, et al.
Gene, 596(6), 119-122 (2017)
Role of PIM2 in allergic asthma
Du Wei, et al.
Molecular Medicine Reports, 16(5), 7504-7512 (2017)
C L Bennett et al.
Immunogenetics, 53(6), 435-439 (2001-10-31)
The mouse scurfy gene, Foxp3, and its human orthologue, FOXP3, which maps to Xp11.23-Xq13.3, were recently identified by positional cloning. Point mutations and microdeletions of the FOXP3 gene were found in the affected members of eight of nine families with
Eleonora Gambineri et al.
Current opinion in rheumatology, 15(4), 430-435 (2003-06-24)
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) is one of a group of clinical syndromes that present with multisystem autoimmune disease suggesting a phenotype of immune dysregulation. Clinically, IPEX manifests most commonly with diarrhea, insulin-dependent diabetes mellitus, thyroid disorders
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