SAB1300464
Anti-WNK1 (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-Lysine deficient 1, Anti-PRKWNK1, Anti-Protein kinase
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... WNK1(65125)
General description
The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]
WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The gene is ubiquitously expressed. The encoded protein contain an active PY motif of short linear proline sequence.
Immunogen
WNK1 (Q9H4A3, 2266-2302)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.
Biochem/physiol Actions
WNK is known to influence the activity of chloride transporters such as members of the SLC12 family. WNK1 regulates ion transportation in kidney and maintains chloride concentration in the neurons. It maintains cell volume during the change in the solute concentration. Osmotic stress and chloride depletion within the cell upregulates WNK1 (WNK lysine deficient protein kinase 1) expression. Mutations in WNK1 leads to familial hyperkalemic hypertension, a Mendelian disorder characterized with thiazide-sensitive hypertension, hyperkalemia, and normal glomerular filtration rate. It is associated with hereditary syndromes like renal disease pseudohypoaldosteronism type II (PHAII) and the neurological disease hereditary sensory neuropathy 2.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Caroline Rooryck et al.
European journal of medical genetics, 52(6), 446-449 (2009-09-08)
We describe a patient presenting with developmental delay, patent foramen ovale, moderate short QT interval, and facial dysmorphism including left microtia, preauricular tag and pit, wide left corner of the mouth, and left hemifacial microsomia, fitting with the oculoauriculovertebral spectrum.
Adriana Mercado et al.
American journal of physiology. Cell physiology, 311(1), C54-C66 (2016-05-14)
The K(+)-Cl(-) cotransporters (KCC1-KCC4) encompass a branch of the SLC12 family of electroneutral cation-coupled chloride cotransporters that translocate ions out of the cell to regulate various factors, including cell volume and intracellular chloride concentration, among others. L-WNK1 is an ubiquitously
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
Roy A
The Journal of Clinical Investigation, 125(9), 3433-3448 (2015)
Ankita Roy et al.
The Journal of clinical investigation, 125(9), 3433-3448 (2015-08-05)
The thiazide-sensitive NaCl cotransporter (NCC) is important for renal salt handling and blood-pressure homeostasis. The canonical NCC-activating pathway consists of With-No-Lysine (WNK) kinases and their downstream effector kinases SPAK and OSR1, which phosphorylate NCC directly. The upstream mechanisms that connect
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
Mercado A
American Journal of Physiology. Cell Physiology, 311(1), C54-C66 (2016)
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