RAB1708
Human SMPD1 ELISA
for serum, plasma and cell culture supernatants
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <12%
intra-assay cv: <10%
shipped in
wet ice
storage temp.
−20°C
Related Categories
General description
Sphingomyelin phosphodiesterase-1 (SMPD1) gene encodes for acid sphingomyelinase (aSMase), which is involved in the hydrolysis of sphingomyelin to ceramides and phosphorylcholine in the late endosomes and lysosomes. Ceramides act as proinflammatory and proapoptotic second messengers. Mutations in the SMPD1 gene are associated with a lack of aSMase, leading to Niemann-Pick disease type A and B. The SMPD1 gene is mapped to the human chromosome at 11p15.1–11p15.4.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible, corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol
Ching Y L, et al.
Human Genetics, 552?562-552?562 (2003)
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