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O1376

Sigma-Aldrich

Orotidine 5′-monophosphate trisodium salt

≥99% (HPLC), powder

Synonym(s):

OMP, Orotidylic acid

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About This Item

Linear Formula:
C10H10N2O11PNa3
CAS Number:
68244-58-6
Molecular Weight:
434.14
MDL number:
MFCD00057417
UNSPSC Code:
41106305
PubChem Substance ID:
24897937
NACRES:
NA.51

Quality Level

200

Assay

≥99% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

[Na].OC1C(O)C(OC1COP(O)(O)=O)N2C(=O)NC(=O)C=C2C(O)=O

InChI

1S/C10H13N2O11P.Na.H/c13-5-1-3(9(16)17)12(10(18)11-5)8-7(15)6(14)4(23-8)2-22-24(19,20)21;;/h1,4,6-8,14-15H,2H2,(H,16,17)(H,11,13,18)(H2,19,20,21);;

InChI key

PSBNOTIIJINWKE-UHFFFAOYSA-N

Application

Orotidine 5′-monophosphate (OMP) is the direct precursor of uridine 5′-monophosphate (UMP) in pyrimidine biosynthesis. OMP is used to study the specificity, kinetics, structures and mechanisms of orotidine 5′-monophosphate decarboxylase(s) (EC 4.1.1.23).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Orotidine 5'-monophosphate decarboxylase (ODCase) is among the most proficient enzymes, and catalyzes the decarboxylation of OMP to UMP. An overview of ODCase and various proposals for its catalytic mechanism of decarboxylation are briefly presented here. A number of inhibitors of
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