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Key Documents

M9434

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody

rat monoclonal, 14

Synonym(s):

Anti-MBP

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About This Item

MDL number:
MFCD01324037
UNSPSC Code:
12352203
NACRES:
NA.41

product name

Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat, clone 14, tissue culture supernatant

biological source

rat

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

14, monoclonal

contains

0.09% sodium azide

species reactivity

horse, chicken, human

technique(s)

ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

isotype

IgG

UniProt accession no.

P02686

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MBP(4155)

General description

Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.

Specificity

Recognizes amino acids 36-50 of myelin basic protein.

Immunogen

bovine myelin basic protein.

Biochem/physiol Actions

Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.

Preparation Note

Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
Neha Soni et al.
Frontiers in neurology, 11, 153-153 (2020-03-27)
Early loss of white matter microstructure integrity is a significant cause of long-term neurological disorders following traumatic brain injury (TBI). White matter abnormalities typically involve axonal loss and demyelination. In-vivo imaging tools to detect and differentiate such microstructural changes are
Frank Rattay et al.
PloS one, 8(11), e79256-e79256 (2013-11-22)
Our knowledge about the neural code in the auditory nerve is based to a large extent on experiments on cats. Several anatomical differences between auditory neurons in human and cat are expected to lead to functional differences in speed and
Chikashi Terao et al.
PloS one, 6(6), e20457-e20457 (2011-06-16)
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study
Angela L Cumberland et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 58, 50-58 (2017-02-14)
Neurosteroids are essential for aiding proper fetal neurodevelopment. Pregnancy compromises such as preterm birth, prenatal stress and intrauterine growth restriction are associated with an increased risk of developing behavioural and mood disorders, particularly during adolescence. These pathologies involve the premature
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