L0669

Monoclonal Anti-Leukemia Inhibitory Factor antibody produced in mouse

clone 9824, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-CDF, Anti-Cholinergic differentiation factor, Anti-HILDA, Anti-LIF
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 9824, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): capture ELISA: 2-4 μg/mL; immunohistochemistry: 25 μg/mL; neutralization: suitable; western blot: 1-2 μg/mL
• UniProt accession no.: P15018
• storage temp.: −20°C
• Gene Information: human ... LIF(3976)

Description

Immunogen

purified, E. coli-derived recombinant human leukemia inhibitory factor.

Biochem/physiol Actions

Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL-6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-c Fos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic cell differentiation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves