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E7909

Sigma-Aldrich

Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-XPO1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~125 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using K562 cell lysates

UniProt accession no.

O14980

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)

General description

Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.

Application

Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CRM1-mediated nuclear export: to the pore and beyond
Hutten S, et al.
Trends in Cell Biology, 193-201 (2007)
Toshie Sakuma et al.
Journal of virology, 88(8), 4069-4082 (2014-01-31)
Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the
J Schmidt et al.
Leukemia, 27(12), 2357-2365 (2013-06-12)
RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export protein. XPO1 expression increases with MM disease progression. Patients with MM have a higher expression of XPO1
Fang Zhou et al.
Medical oncology (Northwood, London, England), 30(4), 726-726 (2013-09-13)
Gastric cancer (GC) is a highly aggressive malignant tumor. Its high mortality rate prompts the urgent need for novel therapeutic agents. The aim of this study is to detect the expression of CRM1 in GC, which has not been reported
Effects of exportin 1 on nuclear transport and meiotic resumption in porcine full-grown and growing oocytes
Onuma A, et al.
Biology of Reproduction, 98(4), 501-509 (2017)
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