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D4162

Sigma-Aldrich

4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt

fluorescent probe

Synonym(s):

Bis-ANS

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About This Item

Empirical Formula (Hill Notation):
C32H22K2N2O6S2
CAS Number:
65664-81-5
Molecular Weight:
672.85
Beilstein:
5714637
MDL number:
MFCD00011592
UNSPSC Code:
12352204
PubChem Substance ID:
24893823
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

form

powder

solubility

methanol with 1 M NH4OH: 5 mg/mL, clear

SMILES string

[K+].[K+].[O-]S(=O)(=O)c1cccc2c(ccc(Nc3ccccc3)c12)-c4ccc(Nc5ccccc5)c6c(cccc46)S([O-])(=O)=O

InChI

1S/C32H24N2O6S2.2K/c35-41(36,37)29-15-7-13-25-23(17-19-27(31(25)29)33-21-9-3-1-4-10-21)24-18-20-28(34-22-11-5-2-6-12-22)32-26(24)14-8-16-30(32)42(38,39)40;;/h1-20,33-34H,(H,35,36,37)(H,38,39,40);;/q;2*+1/p-2

InChI key

VWLWTJHKQHRTNC-UHFFFAOYSA-L

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Application

Bifunctional fluorescent probe for proteins.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Sandip Kumar Nandi et al.
Journal of inorganic biochemistry, 188, 62-75 (2018-08-20)
Mycobacterium leprae uptakes various bivalent metal ions via different transporters in host species. Uptake of Cu2+ and Zn2+ are essential for generation of superoxide dismutases and catalases, which provide defense against reactive oxygen species mediated death of this pathogen in
Cooperative effects in binding by bovine serum albumin. I. The binding of 1-anilino-8-naphthalenesulfonate. Fluorimetric titrations.
E Daniel et al.
Biochemistry, 5(6), 1893-1900 (1966-06-01)
Zsolt Datki et al.
Acta neuropathologica communications, 6(1), 6-6 (2018-01-31)
Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a unique phenomenon that Philodina acuticornis, a bdelloid rotifer, is able to catabolize different types of neurotoxic peptide and protein
A R Prasad et al.
Biochemistry, 25(3), 739-742 (1986-02-11)
The fluorescent apolar probe bis(8-anilinonaphthalene-1-sulfonate) (Bis-ANS) has been used to detect structural correlates of the well-known but poorly understood decay of tubulin function, by which tubulin loses its ability to polymerize and bind drugs in a complex, time-dependent way. The
Fengqi Li et al.
Biomolecules, 9(10) (2019-10-19)
: The whitefly, Bemisiatabaci, is an important invasive economic pest of agricultural crops worldwide. β-ionone has a significant oviposition repellent effect against B.tabaci, but the olfactory molecular mechanism of this insect for recognizing β-ionone is unclear. To clarify the binding
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