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C2365

Sigma-Aldrich

Clofilium tosylate

>97%, solid

Synonym(s):

4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate

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About This Item

Empirical Formula (Hill Notation):
C21H37ClN · C7H7O3S
CAS Number:
92953-10-1
Molecular Weight:
510.17
MDL number:
MFCD00069233
UNSPSC Code:
12352200
PubChem Substance ID:
24892319
NACRES:
NA.77

Quality Level

100

Assay

>97%

form

solid

color

white

solubility

H2O: soluble

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc2ccc(Cl)cc2

InChI

1S/C21H37ClN.C7H8O3S/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-6-2-4-7(5-3-6)11(8,9)10/h14-17H,4-13,18-19H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key

MOQZYUUHIWPDQC-UHFFFAOYSA-M

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Biochem/physiol Actions

K+ channel blocker; cardiac depressant; anti-arrhythmic

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wuyang Wang et al.
The Journal of cell biology, 216(6), 1715-1730 (2017-05-05)
The resting membrane potential (Δψ) of the cell is negative on the cytosolic side and determined primarily by the plasma membrane's selective permeability to K
Clofilium and other class III agents.
Steinberg, et al. et al.
Handbook of Experimental Pharmacology, 89, 389-389 (1989)
Sean A Misek et al.
Molecular pharmacology, 101(1), 1-12 (2021-11-05)
Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal of this study was to use an unbiased computational
Takafumi Kawai et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(51), 26020-26028 (2019-11-30)
The voltage-sensing phosphatase (VSP) is a unique protein that shows voltage-dependent phosphoinositide phosphatase activity. Here we report that VSP is activated in mice sperm flagellum and generates a unique subcellular distribution pattern of PtdIns(4,5)P2 Sperm from VSP-/- mice show more
W B Gough et al.
Cardiovascular research, 23(6), 554-559 (1989-06-01)
To determine whether ischaemic tissue is more sensitive than normal tissue to class III anti-arrhythmic agents, we studied the effects of the class III agents clofilium, d-sotalol and bretylium on normal and ischaemic Purkinje fibres one day after ligation of
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