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A0167

Sigma-Aldrich

Galacto-N-biose

Synonym(s):

β-D-Gal-(1→3)-D-GalNAc, 2-Acetamido-2-deoxy-3-O-β-D-galactopyranosyl-D-galactopyranose, T Antigen

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About This Item

Empirical Formula (Hill Notation):
C14H25NO11
CAS Number:
20972-29-6
Molecular Weight:
383.35
MDL number:
MFCD00063995
UNSPSC Code:
12352201
PubChem Substance ID:
24890406
NACRES:
NA.25

Assay

≥98% (TLC)

form

powder

technique(s)

thin layer chromatography (TLC): suitable

storage temp.

−20°C

SMILES string

CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O

InChI

1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13-,14+/m1/s1

InChI key

HMQPEDMEOBLSQB-UFLFEMAHSA-N

Application

Galacto-N-biose, a component of the galacto-N-biose/lacto-N-biose metabolic pathway, is used as a substrate to identify, differentiate and characterize enzymes such as N-acetylglucosaminyltransferase(s), fucosyl- and sialyltransferase(s), galactosidase(s) and galacto-N-biose/lacto-N-biose I phosphorylase(s) (GLNBP). Galacto-N-biose is used in lectin inhibition studies.

Substrates

A substrate for N-acetylglucosaminyltransferase, fucosyl- and sialyltransferase, and galactosidase. Also used in lectin inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D Williams et al.
The Journal of biological chemistry, 255(23), 11253-11261 (1980-12-10)
The preceding paper (Williams, D., and Schachter, H. (1980) J. Biol. Chem. 255, 0000-0000) described a novel N-acetylglucosaminyltransferase in canine submaxillary gland microsomes which catalyzed the incorporation of GlcNAc into mucin acceptors. We show in the present report that the
T A Beyer et al.
The Journal of biological chemistry, 255(11), 5373-5379 (1980-06-10)
The acceptor substrate specificity and kinetic properties of the purified porcine submaxillary beta-galactoside alpha 1 leads to 2 fucosyltransferase have been examined. The transferase forms the Fuc alpha 1 leads to 2Gal linkage with oligosaccharides, glycoproteins, and glycolipids which contain
S E Tollefsen et al.
The Journal of biological chemistry, 258(8), 5172-5176 (1983-04-25)
We have examined the carbohydrate binding specificity of the B4 lectin from Vicia villosa seeds. The B4 lectin agglutinates Tn-exposed erythrocytes specifically and binds to these erythrocytes (1.4 X 10(6) sites/cell) with an association constant of 4.2 X 10(7) M-1.
D M Moujalled et al.
Cell death & disease, 4, e465-e465 (2013-01-19)
Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent mechanisms. It has been assumed that because RIPK1 bears a death domain (DD), but RIPK3 does not
J I Rearick et al.
The Journal of biological chemistry, 254(11), 4444-4451 (1979-06-10)
The substrate requirements, linkage specificity, and kinetic mechanism of a pure sialyltransferase from porcine submaxillary glands have been examined. The enzyme transfers sialic acid from the donor nucleotide, CMP-NeuAc, into the sequence NeuAcalpha2 leads to 3Galbeta1 leads to 3GalNAc, which
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