SMB00908

4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt

95-105% (titration)

• Synonym(s): 4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt, Parapyruvate
• Linear Formula: C₆H₆K₂O₆
• CAS Number: 19071-44-4
• Molecular Weight: 252.30
• UNSPSC Code: 12352106
• NACRES: NA.25

Properties

• Assay: 95-105% (titration)
• form: powder
• greener alternative product score: old score: 46; new score: 35; Find out more about DOZN™ Scoring
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Design for Energy Efficiency; Design for Degradation; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• color: white to beige
• solubility: water: soluble 10 mg/mL
• greener alternative category: Re-engineered

Description

General description

Parapyruvate, also known as 4-hydroxy-4-methyl-2-oxoglutarate (HMOG), is a compound formed through the polymerization of two molecules of pyruvate via aldol condensation. It is closely related to α-ketoglutarate and is believed to act as a competitive inhibitor of the α-Ketoglutarate dehydrogenase complex (KGDHC) to form succinyl coenzyme A, impacting fibroblast senescence. A decrease in KGDHC activity is also associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s diseases. The precise mechanism of parapyruvate′s inhibition of KGDHC is complex, but it interferes with the activity of this rate-limiting enzyme in the tricarboxylic acid (TCA) cycle, ultimately affecting mitochondrial function. KGDHC is crucial for oxidative decarboxylation within the TCA cycle. Parapyruvate′s potential to inhibit KGDHC paves the way for research in cell biology and biochemistry, covering cell senescence, mitochondrial dysfunction, metabolic regulation, and aging-related diseases.

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, "Energy Efficiency", and “Design for Degradation”. Click here to view its DOZN scorecard.

Application

Parapyruvate can be used

• to study mitochondrial metabolomics
• to study age related disorders (Alzheimer′s and Parkinson′s research)

Biochem/physiol Actions

Parapyruvate is formed via an adol condensation reaction of pyruvate

Features and Benefits

High quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable