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Key Documents

AB9920

Sigma-Aldrich

Anti-Heat Shock Protein 70 (HSP 70) Antibody

serum, Chemicon®

Synonym(s):

Cytochrome P450 3A7

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBI accession no.

NP_005337.2

UniProt accession no.

P08107

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... HSPA1A(3303)
mouse ... Hspa1A(193740)
rat ... Hspa1A(24472)

General description

The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell′s machinery for protein folding, and help to protect cells from stress

Immunogen

Epitope: AA 122 - 400
Recombinant human HSP70

Application

Suggested dilutions:
Western Blot: 1:5000
Detect Heat Shock Protein 70 (HSP 70) using this Anti-Heat Shock Protein 70 (HSP 70) Antibody validated for use in WB.
Research Category
Metabolism
Research Sub Category
Enzymes & Biochemistry

Quality

Routinely evaluated by western blot.

Target description

70 kDa

Physical form

Raw rabbit serum with 0.05% sodium azide.

Storage and Stability

Maintain at -20°C for up to 12 months from date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hsp70 and Hsp90--a relay team for protein folding.
Wegele, H, et al.
Reviews of Physiology, Biochemistry and Pharmacology, 151, 1-44 (2004)
Discovery of the heat shock response.
Ritossa, F
Cell Stress & Chaperones, 1, 97-98 (1996)
New tricks for an old dog: the evolving world of Hsp70.
Morano, Kevin A
Annals of the New York Academy of Sciences, 1113, 1-14 (2007)
Zhenkui Ren et al.
Molecular medicine reports, 22(1), 201-208 (2020-05-08)
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder. Abnormal aggregation of the neurotoxic amyloid‑β (Aβ) peptide is an early event in AD. The activation of astrocytic α7 nicotinic acetylcholine receptor (α7 nAChR) can inhibit Aβ aggregation; thus, the
Astrocyte plasticity revealed by adaptations to severe proteotoxic stress.
Titler, Amanda M, et al.
Cell and Tissue Research, 352, 427-443 (2013)
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