427572

Lactosyl Ceramide, Bovine

A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL.

• Synonym(s): Lactosyl Ceramide, Bovine, Galβ,1,4Glc-Cer, LacCer, LC, LC, Galβ,1,4Glc-Cer, LacCer
• Empirical Formula (Hill Notation): C₅₃H₁₀₁NO₁₃
• CAS Number: 4682-48-8
• Molecular Weight: 960.37
• MDL number: MFCD00133445
• UNSPSC Code: 12352211

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: colorless
• solubility: ethanol: 1 mM; methanol: 1 mM
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C48H91NO13/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-40(53)49-36(37(52)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)35-59-47-45(58)43(56)46(39(34-51)61-47)62-48-44(57)42(55)41(54)38(33-50)60-48/h29,31,36-39,41-48,50-52,54-58H,3-28,30,32-35H2,1-2H3,(H,49,53)/b31-29+/t36?,37?,38-,39-,41+,42+,43-,44-,45-,46+,47-,48?/m1/s1
• InChI key: VOZHMDQUIRUFQW-AIRKALMMSA-N

Description

General description

A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, and c-fos expression in human aortic smooth muscle cells.

A neutral glycosphingolipid (GSL) which is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco- series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase and c-fos expression in human aortic smooth muscle cells.



Molecular weight: 960.4 (based on tricosanyl -23:0)

M.W. 960.4 (based on tricosanoyl - 23:0).

Biochem/physiol Actions

Cell permeable: no

Primary Target
A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Bhunia, A.K., et al. 1997. J. Biol. Chem.272, 15642.
Bhunia, A.K., et al. 1996. J. Biol. Chem.271, 10660.
Zacharias, C., et al. 1994. J. Biol. Chem.269, 13313.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable