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T111

Sigma-Aldrich

8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride

≥98%

Synonym(s):

TMB 8 hydrochloride, TMB-8 · HCl

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About This Item

Linear Formula:
(CH3O)3C6H2CO2(CH2)8N(C2H5)2 · HCl
CAS Number:
53464-72-5
Molecular Weight:
431.99
Beilstein:
5466611
EC Number:
258-574-5
MDL number:
MFCD00012502
UNSPSC Code:
12352100
PubChem Substance ID:
57654652
NACRES:
NA.22

Quality Level

100

Assay

≥98%

form

powder

mp

94-97 °C (lit.)

SMILES string

Cl[H].CCN(CC)CCCCCCCCOC(=O)c1cc(OC)c(OC)c(OC)c1

InChI

1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H

InChI key

KFJZVXKPPQIYCG-UHFFFAOYSA-N

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Application

  • Pharmacologically active inhibitor of hepatitis C virus life cycle

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
FE06041902
FE04012001
FE06221801
FE11172132
FE07211701

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Pierre Poutrain et al.
Journal of experimental botany, 60(4), 1387-1398 (2009-02-17)
Calcium-mediated signalling is ubiquitous in both animals and plants. Changes in cytoplasmic free Ca(2+) concentration couple diverse arrays of stimuli to their specific responses, the specificity of the stimulus being determined by integrated actions between multiple Ca(2+) mobilization pathways. In
Fabián Bernal et al.
Journal of neuroscience research, 87(5), 1240-1249 (2008-11-14)
Human cerebral calcification has been related to deregulation of intracellular calcium homeostasis. In rat basal ganglia, nimodipine and TMB-8, two commonly used calcium antagonists, worsen the chronic AMPA-induced lesion, whereas only nimodipine potentiates calcification. To investigate whether similar effects are
Hiroaki Tosuji et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 147(2), 432-437 (2007-02-24)
During meiosis in oocytes of the starfish, Asterina pectinifera, a Ca(2+) transient has been observed. To clarify the role of Ca(2+) during oocyte maturation in starfish, an intracellular Ca(2+) blocker, TMB-8, was applied. The oocyte maturation induced by 1-methyladenine (1-MA)
Travis J Nickels et al.
Clinical and experimental pharmacology & physiology, 33(5-6), 465-470 (2006-05-17)
1. Theophylline and aminophylline have been widely used as inhibitors of phosphodiesterase when examining the role of cAMP in regulating cell function. In reality, however, these phosphodiesterase inhibitors may have additional sites of action that could complicate the interpretation of
Maria Luisa Zaccardi et al.
Behavioural brain research, 229(1), 235-243 (2012-01-31)
Although habituation is ubiquitous in the animal kingdom, its underlying mechanisms remain poorly understood. In this study, we began to explore the molecular cascades underlying short-term habituation in the leech Hirudo medicinalis. In H. medicinalis, a training paradigm, consisting of
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