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911518

Sigma-Aldrich

Polyester bis-MPA dendron 8 NHBoc, 1 NHS (core)

generation 3

Synonym(s):

Bis-MPA dendron, NHS-NHBoc dendron

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About This Item

Empirical Formula (Hill Notation):
C103H165N9O48
Molecular Weight:
2297.44
UNSPSC Code:
12162002
NACRES:
NA.23

description

8 NHBoc, 1 NHS (core)

form

solid (Viscous)

mol wt

generation 3

no. Surface Groups

8

color

colorless to white

functional group

(NHS(core))

storage temp.

−20°C

General description

  • Polymer architecture: Dendron
  • End Group Functionality: NHBoc
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allows their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers are biocompatible and biodegradable, making them suitable for biomedical applications. The NHBoc-functionalized corona and NHS-functionalized core of this product can be readily used in bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number
MKCL8250

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

The Potential of Dendritic Polyester Scaffolds as Biocompatible Drug Delivery Agents

Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications

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