900913
Tetrazine-PEG5-NHS ester
≥95%
Synonym(s):
Tz-PEG5-NHS
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About This Item
Empirical Formula (Hill Notation):
C27H36N6O10
CAS Number:
Molecular Weight:
604.61
MDL number:
UNSPSC Code:
12352108
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistry
reagent type: linker
functional group
NHS ester
storage temp.
−20°C
SMILES string
O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
General description
Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
Application
Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Bioconjugate chemistry, 26(4), 782-789 (2015-03-12)
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