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61250

Sigma-Aldrich

DL-Kynurenine

≥95.0% (NT), for peptide synthesis

Synonym(s):

2-Amino-3-(2-aminobenzoyl)propionic acid, 2-Amino-4-(2-aminophenyl)-4-oxobutyric acid

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O3
CAS Number:
343-65-7
Molecular Weight:
208.21
Beilstein:
2697333
EC Number:
206-445-9
MDL number:
MFCD00025194
UNSPSC Code:
12352209
PubChem Substance ID:
57651839
NACRES:
NA.22

product name

DL-Kynurenine, ≥95.0% (NT)

Assay

≥95.0% (NT)

form

powder

mp

~235 °C (dec.)

application(s)

peptide synthesis

SMILES string

NC(CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)

InChI key

YGPSJZOEDVAXAB-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adam K Walker et al.
Molecular psychiatry, 24(10), 1523-1532 (2018-07-11)
Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. Circulating kynurenine is transported into the brain by the large amino transporter LAT1 at the level of the blood-brain barrier. We hypothesized that administration of leucine that has a high
Ye Lu et al.
Journal of clinical biochemistry and nutrition, 58(3), 210-215 (2016-06-04)
Postoperative fatigue syndrome is a general complication after surgery. However, there is no ''gold standard'' for fatigue assessment due to the lack of objective biomarkers. In this study, a rodent model of postoperative fatigue syndrome based on partial hepatectomy was
Alban Bessede et al.
Nature, 511(7508), 184-190 (2014-06-17)
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide
László Vécsei et al.
Nature reviews. Drug discovery, 12(1), 64-82 (2012-12-15)
Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its metabolites are responsible for a broad spectrum of effects, including the endogenous regulation
Soo Ching Lee et al.
Scientific reports, 8(1), 14277-14277 (2018-09-27)
We explored the gut microbiota profile among HIV-infected individuals with diverse immune recovery profiles following long-term suppressive ART and investigated the relationship between the altered bacteria with markers of immune dysfunction. The microbiota profile of rectal swabs from 26 HIV-infected
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