Skip to Content
Merck
All Photos(1)

Documents

195421

Sigma-Aldrich

10,11-Dihydrocarbamazepine

99%

Synonym(s):

10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C15H14N2O
CAS Number:
3564-73-6
Molecular Weight:
238.28
EC Number:
222-649-0
MDL number:
MFCD00005072
UNSPSC Code:
12352100
PubChem Substance ID:
24851693
NACRES:
NA.22

Assay

99%

form

solid

mp

205-210 °C (lit.)

solubility

dichloromethane: soluble 2.5%, clear, colorless

SMILES string

NC(=O)N1c2ccccc2CCc3ccccc13

InChI

1S/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)

InChI key

PHNLCHMJDSSPDQ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

10,11-Dihydrocarbamazepine is an impurity present in dibenzazepine drug used in the treatment of epilepsy. Single-crystal structure of new dimer-based polymorph of 10,11-dihydrocarbamazepine has been investigated.

Application

10,11-Dihydrocarbamazepine was used as internal standard during simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. It was used in chemiluminescence method for determination of carbamazepine.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H317,H336,H360D

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Skin Sens. 1A - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sang Hak Lee et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 19(6), 903-906 (2003-07-02)
A new chemiluminescence method for the determination of carbamazepine (CBZ) has been developed. The method is based on the chemiluminescence produced in the reaction of tris(2,2'-bipyridine)ruthenium(III) and CBZ in an acidic medium. The chemiluminescence intensity was enhanced by organic solvents
A predicted dimer-based polymorph of 10, 11-dihydrocarbamazepine (Form IV).
Arlin J-B, et al.
CrystEngComm, 12(1), 64-66 (2010)
M Eichelbaum et al.
Journal of chromatography, 103(1), 135-140 (1975-01-14)
A liquid-chromatographic method for the simultaneous determination of carbamazepine and its active metabolite (carbamazepine 10,11-epoxide) in plasma has been developed. The two compounds were identified in plasma by mass spectrometry. The lower limit of sensitivity is about 4 and 40
William T A Harrison et al.
Acta crystallographica. Section C, Crystal structure communications, 62(Pt 5), o240-o242 (2006-05-09)
The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The molecular conformations of both forms are very similar, involving a bent conformation for the seven-membered azepine ring and
M G Bixel et al.
European journal of biochemistry, 267(1), 110-120 (1999-12-22)
Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the structure of PhTXs and poly(methylene tetramine)s on the binding affinity have been investigated. Using the
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service