PRKCA
protein kinase C, alpha
Synonyms:
AAG6, PKC-alpha, PKCA, PRKACA
Species:
Human PRKCA (5578), Mouse Prkca (18750), Rat Prkca (24680), cow PRKCA (282001), sheep PRKCA (101110074), naked mole-rat Prkca (101716044), Domestic Rabbit PRKCA (100037720), domestic guinea pig Prkca (100302324), domestic guinea pig Prkca (100713627), Zebrafish prkca (497384) ...More
UniProtKB ID:
Gene ID:
- Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
- Mouse(18750) protein kinase C, alpha
- Rat(24680) protein kinase C, alpha
- cow(282001) protein kinase C, alpha
- sheep(101110074) protein kinase C, alpha
- naked mole-rat(101716044) protein kinase C, alpha
- Domestic Rabbit(100037720) protein kinase C, alpha
- domestic guinea pig(100302324) protein kinase C, alpha
- domestic guinea pig(100713627) protein kinase C, alpha
- Zebrafish(497384) protein kinase C, alpha
- domestic cat(101086433) protein kinase C, alpha
- Horse(100063318) protein kinase C, alpha
- dog(490904) protein kinase C, alpha
- chicken(417430) protein kinase C, alpha
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Small Molecule - Activator
Product Number
Description
Species
Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-PKCα (Ser657/Tyr658) Antibody, Upstate®, from rabbit,
Species Reactivity
human, rabbit, rat
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Species
human
Small Molecule - Substrate
Product Number
Description
Species