20-133-M

PKC Lipid Activator

• Synonym(s): PKC activator, Protein kinase C activator
• UNSPSC Code: 41116012
• eCl@ss: 32160405
• NACRES: NA.41

Properties

• form: liquid
• Quality Level: 100
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (kinase)
• NCBI accession no.: NM_002737.2
• UniProt accession no.: P17252
• Gene Information: human ... PRKCA(5578)

Description

General description

Protein kinase C (PKC) belongs to a family of serine/ threonine kinases. It comprises a regulatory domain at the N-terminus and a catalytic domain at the C-terminus. The regions are divided into conserved regions (C1–C4) and regions that differ between isoforms (V1–V5). PKC has a common pseudosubstrate domain in the regulatory region.

Application

For use in kinase assays.

Research Category
All

Biochem/physiol Actions

Protein kinase C (PKC) is activated by diacylglycerol (DAG) and acts as an intracellular receptor of tumor-promoting phorbol esters. It regulates several cell functions and signal transduction pathways through cell migration and polarity, differentiation, proliferation, and cell death. PKC is part of a large group of phospholipid-dependent enzymes, which catalyze the covalent transfer of phosphate from ATP to serine and threonine residues of proteins.

Physical form

20mM MOPS, pH 7.2, 25mM β-glycerolphosphate, 1mM sodium orthovanadate, 1mM dithiothreitol, 1mM CaCl2.

Storage and Stability

1 year at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable