APC
adenomatous polyposis coli
Synonyms:
BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
Species:
Human APC (324), Mouse Apc (11789), Rat Apc (24205), sheep APC (101104664), domestic guinea pig Apc (100723694), naked mole-rat Apc (101704055), Zebrafish apc (386762), fruit fly Apc (44642), cow APC (533233), Horse APC (100064431) ...More
UniProtKB ID:
Gene ID:
- Human(324) Summary: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
- Mouse(11789) adenomatosis polyposis coli
- Rat(24205) adenomatous polyposis coli
- sheep(101104664) adenomatous polyposis coli
- domestic guinea pig(100723694) adenomatous polyposis coli
- naked mole-rat(101704055) adenomatous polyposis coli
- Zebrafish(386762) adenomatosis polyposis coli
- fruit fly(44642) APC-like
- cow(533233) adenomatous polyposis coli
- Horse(100064431) adenomatous polyposis coli
- domestic cat(101096138) adenomatous polyposis coli
- dog(479139) adenomatous polyposis coli
- chicken(415607) adenomatous polyposis coli
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-APC Antibody, CT, clone C-APC 28.9, clone C-APC 28.9, Chemicon®, from mouse,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-APC Antibody, NT, clone Ali 12.28, clone Ali 12.28, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot