- Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.
Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.
Molecules (Basel, Switzerland) (2015-10-02)
Thomas M Kohl, Christian H Hornung, John Tsanaktsidis
PMID26426000
ABSTRACT
Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications
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