Adapalene: an update on newer comparative studies between the various retinoids.

Extensive modification of the retinoic acid molecular skeleton has resulted in the development of adapalene, a more stable, less irritating compound with receptor selectivity. Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis. Pharmacologic and preclinical studies have demonstrated excellent follicular penetration, comedolytic activity, and anti-inflammatory activity. Recent comparative trials were reviewed. Adapalene is a useful new agent because of its tolerability and stability. It is a good therapeutic choice for combination with other topical anti-acne medications, such as antimicrobials or benzoyl peroxide. Patient compliance with either combination or single-agent adapalene regimens is likely to be enhanced because of the greater comfort and reduced skin irritation associated with the new compound. Other investigators have confirmed that adapalene gel produces consistent and significantly reduced irritation. Recent comparative trials on retinoids have provided new data to aid in the selection of the appropriate combination of topical agents for individual patients.