Skip to Content
Merck
  • Exploring mechanisms of FGF signalling through the lens of structural biology.

Exploring mechanisms of FGF signalling through the lens of structural biology.

Nature reviews. Molecular cell biology (2013-02-14)
Regina Goetz, Moosa Mohammadi
ABSTRACT

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing and adult organism. The accumulated wealth of structural information on the FGF signalling pathway has begun to unveil the underlying molecular mechanisms that modulate this system to generate a myriad of distinct biological outputs in development, tissue homeostasis and metabolism. At the ligand and receptor level, these mechanisms include alternative splicing of the ligand (FGF8 subfamily) and the receptor (FGFR1-FGFR3), ligand homodimerization (FGF9 subfamily), site-specific proteolytic cleavage of the ligand (FGF23), and interaction of the ligand and the receptor with heparan sulphate cofactor and Klotho co-receptor.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type HP-2, aqueous solution, ≥100,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type HP-2S, aqueous solution, ≥90,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-5, lyophilized powder, ≥400,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-3, aqueous solution, ≥90,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-1, partially purified powder, ≥300,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-3AF, aqueous solution, ≥60,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-2, aqueous solution, ≥85,000 units/mL
Sigma-Aldrich
β-Glucuronidase from limpets (Patella vulgata), Type L-II, lyophilized powder, 1,000,000-3,000,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from bovine liver, Type B-1, ≥1,000,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, aqueous glycerol solution, ≥5,000,000 units/g protein, pH 6.8 (biuret)
Sigma-Aldrich
β-Glucuronidase from bovine liver, Type B-3, ≥2,000,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, Type VII-A, lyophilized powder, 5,000,000-20,000,000 units/g protein, pH 6.8 (30 min assay)
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, Type IX-A, lyophilized powder, 1,000,000-5,000,000 units/g protein (30 min assay)
Sigma-Aldrich
β-Glucuronidase from Helix aspersa (garden snail), Type HA-4
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, ≥20,000 units/mg protein, recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, >20,000,000 units/g protein, recombinant, expressed in E. coli, aqueous glycerol solution
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, ≥10,000,000 units/g protein (30 min assay), recombinant, expressed in E. coli overproducing strain, lyophilized powder