- Identification of Annexin A2 as a target protein for plant alkaloid matrine.
Identification of Annexin A2 as a target protein for plant alkaloid matrine.
Chemical communications (Cambridge, England) (2017-04-22)
Dongyao Wang, Yan Cao, Leyi Zheng, Diya Lv, Langdong Chen, Xinrui Xing, Zhenyu Zhu, Xiaoyu Li, Yifeng Chai
PMID28428997
ABSTRACT
Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.
MATERIALS