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  • Microwave-assisted, boron trichloride mediated acylation of phenols-synthesis of (o-hydroxyaryl)(aryl)methanones and xanthones.

Microwave-assisted, boron trichloride mediated acylation of phenols-synthesis of (o-hydroxyaryl)(aryl)methanones and xanthones.

Journal of combinatorial chemistry (2006-05-09)
Lei Zhang, John Y Zhang
ABSTRACT

A novel and efficient microwave-assisted, BCl(3) mediated coupling reaction to synthesize o-(hydroxyaryl)(aryl)methanone structures from phenols and acyl chlorides is described. This reaction was further incorporated into a two-step synthesis of biologically interesting xanthones.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boron trichloride solution, 1.0 M in methylene chloride
Sigma-Aldrich
Boron trichloride solution, 1.0 M in heptane
Sigma-Aldrich
Boron trichloride solution, 1.0 M in p-xylene
Sigma-Aldrich
Boron trichloride solution, 1.0 M in toluene