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  • Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.

Science (New York, N.Y.) (1995-12-22)
K Yamaguchi, K Shirakabe, H Shibuya, K Irie, I Oishi, N Ueno, T Taniguchi, E Nishida, K Matsumoto
ABSTRACT

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
TAK1-TAB1 (1-303), (437-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
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