PZ0016

Dofetilide

≥98% (HPLC), powder, hERG channel blocker

• Synonym(s): N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, UK-68798
• Empirical Formula (Hill Notation): C₁₉H₂₇N₃O₅S₂
• CAS Number: 115256-11-6
• Molecular Weight: 441.56
• MDL number: MFCD00869707
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823685
• NACRES: NA.77

Properties

• product name: Dofetilide, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
• InChI key: IXTMWRCNAAVVAI-UHFFFAOYSA-N
• Gene Information: human ... KCNH2(3757)

Description

Biochem/physiol Actions

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H360,H373,H411
• Precautionary Statements: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Chronic 2 - Repr. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable