G119

GYKI 52466 hydrochloride

solid

• Synonym(s): 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₁₅N₃O₂ · HCl
• CAS Number: 192065-56-8
• Molecular Weight: 329.78
• MDL number: MFCD00153803
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277984
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• color: yellow
• solubility: DMSO: 0.39 mg/mL; ethanol: 0.4 mg/mL; 0.1 M HCl: 0.68 mg/mL; methanol: 1 mg/mL; H₂O: >10 mg/mL
• SMILES string: Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
• InChI: 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
• InChI key: RUBSCPARMVJNKX-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Description

Application

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

Biochem/physiol Actions

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.

Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves