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G2417

Supelco

Gabexate mesylate

analytical standard, for drug analysis

Synonym(s):

4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxyl]benzoic acid ethyl ester mesylate salt, FOY, Megacart

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About This Item

Empirical Formula (Hill Notation):
C16H23N3O4 · CH4O3S
CAS Number:
56974-61-9
Molecular Weight:
417.48
MDL number:
MFCD00210299
UNSPSC Code:
41116107
PubChem Substance ID:
329799903
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

200

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI

1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

InChI key

DNTNDFLIKUKKOC-UHFFFAOYSA-N

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General description

Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
081K1764

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Manabu Hayata et al.
American journal of physiology. Renal physiology, 303(8), F1126-F1135 (2012-07-27)
The number of the chronic renal failure (CRF) patients is increasing explosively. Hypertension, proteinuria, inflammation, fibrosis, and oxidative stress are intertwined in a complicated manner that leads to the progression of CRF. However, the therapeutic strategies to delay its progression
Dalya M Lateef et al.
Peptides, 32(6), 1289-1295 (2011-04-02)
Camostat mesilate (or mesylate) releases endogenous cholecystokinin (CCK) or CCK-58, the only detectable endocrine form of CCK in the rat, and reduces cumulative food intake by activating CCK(1) receptor. However, the literature lacks meal pattern analysis and an appropriate dose-response
Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug.
Erba F, et al.
Biochemical Pharmacology, 61(3), 271-276 (2001)
Myung Jin Oh et al.
Scandinavian journal of gastroenterology, 47(8-9), 1071-1077 (2012-09-01)
Although endoscopic papillary large balloon dilation (EPLBD) with limited endoscopic sphincterotomy (ES) showed excellent outcomes for treatment of large bile duct stones, hemorrhage and recurrence of stones are problematic complications. Recent studies suggest that EPLBD alone is safe and effective
Giovanni Brandi et al.
PloS one, 7(7), e41347-e41347 (2012-08-23)
The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and
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Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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