TCF3
transcription factor 3
Synonyms:
E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
Species:
Human TCF3 (6929), Mouse Tcf3 (21423), Rat Tcf3 (171046), domestic guinea pig Tcf3 (100733634), naked mole-rat Tcf3 (101725133), cow TCF3 (530616), sheep TCF3 (100913162), chicken TCF3 (395146), Horse TCF3 (100147220), domestic cat TCF3 (101098930)
UniProtKB ID:
Gene ID:
- Human(6929) Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
- Mouse(21423) transcription factor 3
- Rat(171046) transcription factor 3
- domestic guinea pig(100733634) transcription factor 3
- naked mole-rat(101725133) transcription factor 3
- cow(530616) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- sheep(100913162) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- chicken(395146) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- Horse(100147220) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- domestic cat(101098930) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- dog(485079) transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TCF3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-TCF3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-TCF3 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
dog, guinea pig, human, mouse, rat
Application
western blot
Anti-TCF3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-TCF3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot