PSEN2
presenilin 2 (Alzheimer disease 4)
Synonyms:
AD3L, AD4, CMD1V, PS2, STM2
Species:
Human PSEN2 (5664), Mouse Psen2 (19165), Rat Psen2 (81751), Zebrafish psen2 (58026), dog PSEN2 (490382), domestic cat PSEN2 (101081693), chicken PSEN2 (374188), Domestic Rabbit PSEN2 (100343671), cow PSEN2 (282010), sheep PSEN2 (101113776)
UniProtKB ID:
Gene ID:
- Human(5664) Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- Mouse(19165) presenilin 2
- Rat(81751) presenilin 2
- Zebrafish(58026) presenilin 2
- dog(490382) presenilin 2 (Alzheimer disease 4)
- domestic cat(101081693) presenilin 2 (Alzheimer disease 4)
- chicken(374188) presenilin 2 (Alzheimer disease 4)
- Domestic Rabbit(100343671) presenilin 2 (Alzheimer disease 4)
- cow(282010) presenilin 2 (Alzheimer disease 4)
- sheep(101113776) presenilin 2 (Alzheimer disease 4)
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSEN2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-Pen-2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species