NR3C2
nuclear receptor subfamily 3, group C, member 2
Synonyms:
MCR, MLR, MR, NR3C2VIT
Species:
Human NR3C2 (4306), Mouse Nr3c2 (110784), Rat Nr3c2 (25672), Zebrafish nr3c2 (562171), dog NR3C2 (475461), cow NR3C2 (280861), cow NR3C2 (537614), Horse NR3C2 (100062570), domestic cat NR3C2 (101081977), chicken NR3C2 (374131) ...More
UniProtKB ID:
Gene ID:
- Human(4306) Summary: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- Mouse(110784) nuclear receptor subfamily 3, group C, member 2
- Rat(25672) nuclear receptor subfamily 3, group C, member 2
- Zebrafish(562171) nuclear receptor subfamily 3, group C, member 2
- dog(475461) nuclear receptor subfamily 3, group C, member 2
- cow(280861) nuclear receptor subfamily 3, group C, member 2
- cow(537614) nuclear receptor subfamily 3, group C, member 2
- Horse(100062570) nuclear receptor subfamily 3, group C, member 2
- domestic cat(101081977) nuclear receptor subfamily 3, group C, member 2
- chicken(374131) nuclear receptor subfamily 3, group C, member 2
- sheep(101107046) nuclear receptor subfamily 3, group C, member 2
- domestic guinea pig(100735309) nuclear receptor subfamily 3, group C, member 2
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Small Molecule - Agonist
Product Number
Description
Species
Deoxycorticosterone acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Small Molecule - Antagonist
Product Number
Description
Species
Eplerenone for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Eplerenone for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NR3C2, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
horse, human
Application
western blot
Anti-NR3C2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human, rabbit
Application
immunohistochemistry
western blot
western blot
Anti-NR3C2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-Mineralocorticoid Receptor Antibody, clone 6G1, clone 6G1, from mouse,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Mineralocorticoid Receptor Antibody, clone 2D6, clone 2D6, from mouse,
Species Reactivity
rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot