MDC1
mediator of DNA-damage checkpoint 1
Synonyms:
NFBD1
Species:
Human MDC1 (9656), Mouse Mdc1 (240087), Rat Mdc1 (309595), chicken MDC1 (101664732), chicken MDC1 (101751335), cow MDC1 (511168), Horse MDC1 (100055473), domestic cat MDC1 (101095415), dog MDC1 (474829), sheep MDC1 (101107143) ...More
UniProtKB ID:
Gene ID:
- Human(9656) Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
- Mouse(240087) mediator of DNA damage checkpoint 1
- Rat(309595) mediator of DNA damage checkpoint 1
- chicken(101664732) mediator of DNA-damage checkpoint 1
- chicken(101751335) mediator of DNA-damage checkpoint 1
- cow(511168) mediator of DNA-damage checkpoint 1
- Horse(100055473) mediator of DNA-damage checkpoint 1
- domestic cat(101095415) mediator of DNA-damage checkpoint 1
- dog(474829) mediator of DNA-damage checkpoint 1
- sheep(101107143) mediator of DNA-damage checkpoint 1
- domestic guinea pig(100721744) mediator of DNA-damage checkpoint 1
- naked mole-rat(101702518) mediator of DNA-damage checkpoint 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MDC1 antibody, Mouse monoclonal, clone MDC1-50, purified from hybridoma cell culture,
Species Reactivity
human, monkey
Application
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
ANTI-MDC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-MDC1 antibody produced in mouse, clone P2B11, 1 mg/mL, purified immunoglobulin,
Species Reactivity
bovine, chimpanzee, human, mouse
Application
immunofluorescence
western blot
western blot
Rabbit anti-MDC1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-MDC1 (pSer513) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry