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Merck

CACNA2D3

calcium channel, voltage-dependent, alpha 2/delta subunit 3

Synonyms:
HSA272268
Species:
UniProtKB ID:
Gene ID:
  • Human(55799) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(12294) calcium channel, voltage-dependent, alpha2/delta subunit 3
  • Rat(306243) calcium channel, voltage-dependent, alpha2/delta subunit 3
  • naked mole-rat(101712827) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • domestic guinea pig(100724165) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • sheep(101105365) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Zebrafish(100535196) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • cow(519644) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Horse(100059197) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • domestic cat(101094658) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • dog(476585) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • chicken(415996) calcium channel, voltage-dependent, alpha 2/delta subunit 3
  • Zebrafish(100148645) calcium channel, voltage dependent, alpha2/delta subunit 3

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Gabapentin, solid,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-CACNA2D3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Bepridil hydrochloride, powder,
Species
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA2D3,
Species
human