G006152

LC/MS (TOF) Analysis of 2C Amine Drugs of Abuse on Ascentis^® Express HILIC

application for HPLC

Properties

• technique(s): HPLC: suitable
• test parameters: column: Ascentis Express HILIC, 5 cm x 2.1 mm I.D., 2.7 μm particles (53934-U); mobile phase: 2 mM ammonium formate in 90:10 (v:v) acetonitrile:water; flow rate: 0.4 mL/min; pressure: 943 psi (65 bar); column temp.: 35 °C; detector: TOF/MS; injection: 2 μL; sample: 300 ng/mL in acetonitrile
• suitability: application for HPLC
• application(s): forensics and toxicology

Description

Analysis Note

The 2C amines are a family of illicit, psychedelic phenethylamines. The term "2C" refers to the two carbon atoms between the benzene ring and the amino group in the parent molecular structure. A rapid separation of four 2C amine compounds is shown here on an Ascentis Express HILIC column with TOF-MS detection. Cerilliant CRMs were used to ensure reliable MS identification and quantification.

Legal Information

Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

(R)-(-)-Bromo-DragonFLY hydrochloride solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®
2,5-Dimethoxy-4-(n)-propylthiophenethylamine hydrochloride solution, 1.0 mg/mL in acetonitrile: water (9:1) (as free base), ampule of 1 mL, certified reference material, Cerilliant^®
4-Bromo-2,5-dimethoxyphenethylamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®
2C-B-FLY hydrochloride solution, 1 mg/mL in acetonitrile: water (9:1), ampule of 1 mL, certified reference material, Cerilliant^®