T9701
TRAIL human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder
Synonym(s):
Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
description
extracellular domain
Assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
mol wt
19.6 kDa
predicted mol wt ~21 kDa
technique(s)
immunofluorescence: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFSF10(8743)
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Application
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
Biochem/physiol Actions
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
Physical form
Lyophilized from phosphate buffered saline
Analysis Note
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a potential anti-cancer activity that is widely used
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