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SML0255

Sigma-Aldrich

4-DAMP

≥98% (HPLC)

Synonym(s):

1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide, 4-DAMP methiodide, 4-Diphenylacetoxy-N-methylpiperidine methiodide, 4-[(Diphenylacetyl)oxy]-1,1-dimethyl-piperidinium iodide

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About This Item

Empirical Formula (Hill Notation):
C21H26INO2
CAS Number:
1952-15-4
Molecular Weight:
451.34
MDL number:
MFCD00078564
UNSPSC Code:
12352200
PubChem Substance ID:
329825263
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥15 mg/mL

storage temp.

room temp

SMILES string

[I-].C[N+]1(C)CCC(CC1)OC(=O)C(c2ccccc2)c3ccccc3

InChI

1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1

InChI key

WWJHRSCUAQPFQO-UHFFFAOYSA-M

Biochem/physiol Actions

4-DAMP is a M3 preferring cholinergic receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
075M4727V
114M4722V
062M4721V
022M4719V

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Our previous results (Nakamura et al., 2013, 2016) indicated that acetylcholine (ACh) in orally administered foods exerts antihypertensive effects. Eggplants (Solanum melongena) contain abundant ACh (Horiuchi et al., 2003), and their food functionality was discovered, using spontaneously hypertensive rats, by
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Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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