SMB00292
Fengycin
≥90%
Synonym(s):
Fengycin, Plipastatin
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About This Item
Empirical Formula (Hill Notation):
C72H110N12O20
Molecular Weight:
1463.71
UNSPSC Code:
51102829
NACRES:
NA.85
biological source
Bacillus subtilis
Assay
≥90%
form
powder
color
, Off-White to Light Yellow to Light Brown
antibiotic activity spectrum
fungi
Mode of action
cell membrane | interferes
storage temp.
2-8°C
General description
Chemical structure: peptide
Fengycin is a lipopeptide complex which is synthesized by Bacillus subtilis strain F-29-3. It is an antifungal compound, and is made up of two components namely, fengycin A and fengycin B. Fengycin A contains 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-Glx, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas fengycin B contains D-Val instead of D-Ala.
Application
Fengycin may be used for the sterilization of E. coli., and for the inactivation of spores of Bacillus cereus.
Biochem/physiol Actions
Fengycin shows antifungal properties against filamentous fungi, but has no action against yeast and bacteria. Certain unsaturated fatty acids facilitate the antifungal property, whereas sterols, phospholipids and oleic acid act as antagonists. It produces morphological abnormalities in fungi including curling, bulging and empyting of hyphae. Thus, it mainly functions through its effects on the plasma membrane.
Packaging
5MG
Storage and Stability
Store at 2 to 8 °C. (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Antifungal effects of bacilysin and fengymycin from Bacillus subtilis F-29-3 a comparsion with activities of other Bacillus antibiotics.
Loeffler W., et al
Journal of Phytopathology, 115, 204-213 (1986)
Optimization of inactivation of endospores of Bacillus cereus in milk by surfactin and fengycin using a response surface method.
Huang X
International Journal of Peptide Research and Therapeutics, 14(2), 89-95 (2008)
Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67
Nishikiori, T., et al
The Journal of Antibiotics, 39, 745-745 (1986)
Marc Ongena et al.
Environmental microbiology, 9(4), 1084-1090 (2007-03-16)
Multiple strains of Bacillus spp. were demonstrated to stimulate plant defence responses. However, very little is known about the nature of molecular determinants secreted by these Gram-positive bacteria that are responsible for the elicitation of the induced systemic resistance (ISR)
N Vanittanakom et al.
The Journal of antibiotics, 39(7), 888-901 (1986-07-01)
Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase
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