R6527

Reboxetine mesylate hydrate

>96% (HPLC), solid

• Synonym(s): (2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra
• Empirical Formula (Hill Notation): C₁₉H₂₃NO₃ · CH₃SO₃H · xH₂O
• CAS Number: 98769-84-7
• Molecular Weight: 409.50 (anhydrous basis)
• MDL number: MFCD11046031
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724592
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >96% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: >5 mg/mL at ≤60 °C
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3
• InChI: 1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
• InChI key: SZPHEVAYLIVGRC-BAMQSBMESA-N

Description

Application

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:

• to study its effects on the surge of dopamine in the cortex of mice brain
• to study its anti-immobility effects on the behavior of mice
• to analyze its effects on the probabilistic reversal learning task in rodents

Biochem/physiol Actions

Reboxetine exhibits anti-depressant activity.

Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves