PLA0132

Rabbit anti-Sirt1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): SIR2, SIR2-like protein 1, SIR2L1, SIR2alpha, hSIR2, hSIRT1, homolog) 1, regulatory protein SIR2 homolog 1, sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), sirtuin (silent mating type information regulation 2; S. cerevisiae, sirtuin type 1
• UNSPSC Code: 12352203
• NACRES: NA.41
• species reactivity: human
• application: IP; WB
• technique(s): immunoprecipitation (IP): 1-4 μg/mg; western blot: 1:2,000- 1:10,000
• citations: 8

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: human
• technique(s): immunoprecipitation (IP): 1-4 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_036370.2
• UniProt accession no.: Q96EB6
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: rabbit ... Sirt1(23411)

Description

Immunogen

The epitope recognized by PLA0132 maps to a region between residue 700 and the C-terminus (residue 747) of human Silent Mating Type Information Regulation 2 homolog 1 using the numbering given in entry NP_036370.2 (GeneID 23411).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD÷-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable