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P0618

Sigma-Aldrich

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide

≥98% (HPLC), solid

Synonym(s):

cis(±)-8-OH-PBZI hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C15H21NO · HBr
Molecular Weight:
312.25
MDL number:
MFCD11045999
UNSPSC Code:
12352202
PubChem Substance ID:
24278794
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

light brown

solubility

H2O: soluble ~10 mg/mL at 60 °C (Sonicate)
DMSO: soluble 12 mg/mL

storage temp.

2-8°C

SMILES string

Br.CCCN1CC[C@@H]2[C@H]1CCc3ccc(O)cc23

InChI

1S/C15H21NO.BrH/c1-2-8-16-9-7-13-14-10-12(17)5-3-11(14)4-6-15(13)16;/h3,5,10,13,15,17H,2,4,6-9H2,1H3;1H/t13-,15+;/m0./s1

InChI key

UMGQLEXNQCHIFN-NQQJLSKUSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

D3 dopamine receptor agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E V Kuzhikandathil et al.
Pharmaceutical research, 29(8), 2264-2275 (2012-05-02)
The D3 dopamine receptor exhibits tolerance and slow response termination (SRT) properties that are not exhibited by the closely-related D2 dopamine receptor. We previously demonstrated that the induction of tolerance elicits a unique conformational change in the D3 receptor. Here
Ligia Westrich et al.
Biochemical pharmacology, 79(6), 897-907 (2009-11-03)
The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediated by receptor internalization, persistent

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