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P0358

Sigma-Aldrich

Anti-Potassium Channel Kv4.3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-BRGDA9, Anti-KCND3L, Anti-KCND3S, Anti-KSHIVB, Anti-KV4.3, Anti-SCA19, Anti-SCA22

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About This Item

MDL number:
MFCD02097221
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot (chemiluminescent): 1:200

UniProt accession no.

Q9UK17

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCND3(3752)
rat ... Kcnd3(65195)

General description

Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the Ito channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.

Immunogen

synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel Kv4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).

Application

Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H312 + H332,H412

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yi-Chung Lee et al.
Annals of neurology, 72(6), 859-869 (2013-01-03)
To identify the causative gene in spinocerebellar ataxia (SCA) 22, an autosomal dominant cerebellar ataxia mapped to chromosome 1p21-q23. We previously characterized a large Chinese family with progressive ataxia designated SCA22, which overlaps with the locus of SCA19. The disease
P Serôdio et al.
Journal of neurophysiology, 75(5), 2174-2179 (1996-05-01)
1. Proteins of the Kv4 or Shal-related subfamily are key components of transient K+ channels (A channels) operating at subthreshold values of the membrane potential. We have cloned and characterized a new mammalian Kv4 or Shal-related cDNA (Kv4.3) that predicts
J E Dixon et al.
Circulation research, 79(4), 659-668 (1996-10-01)
The expression of 15 different K+ channels in canine heart was examined, and a new K+ channel gene (Kv4.3), which encodes a rapidly inactivating K+ current, is described. The Kv4.3 channel was found to have biophysical and pharmacological properties similar
F C Howarth et al.
Molecular and cellular biochemistry, 328(1-2), 57-65 (2009-03-10)
Ventricular electrical conduction has been investigated in the streptozotocin (STZ)-induced diabetic rat. Diabetes was induced with a single injection of STZ (60 mg/kg bodyweight, ip). The ECG was measured continuously, in vivo, using a biotelemetry system. Left ventricular action potentials
S Ohya et al.
FEBS letters, 420(1), 47-53 (1998-02-05)
We describe here (1) the heterogeneous expression of Ca2+-independent transient (A-type) K+ channel alpha-subunits (Kv1.4, Kv3.3, Kv3.4, Kv4.2 and Kv4.3) in rat smooth muscle, heart and brain, (2) the molecular cloning and tissue distribution of a novel alternatively spliced variant
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