N8509

N-Nitroso-N-ethylurea

Bulk package

• Synonym(s): ENU, N-Ethyl-N-nitrosourea
• Empirical Formula (Hill Notation): C₃H₇N₃O₂
• CAS Number: 759-73-9
• Molecular Weight: 117.11
• EC Number: 212-072-2
• MDL number: MFCD00053635
• UNSPSC Code: 12352102
• PubChem Substance ID: 24897681
• NACRES: NA.25

Properties

• form: powder
• contains: aqueous acetic acid as stabilizer
• storage temp.: −20°C
• SMILES string: CCN(N=O)C(N)=O
• InChI: 1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
• InChI key: FUSGACRLAFQQRL-UHFFFAOYSA-N

Description

Application

• Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.: This study identifies genetic factors affecting blood pressure and heart rate using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis. The research utilizes automated meiotic mapping to reveal the genetic underpinnings of these cardiovascular traits, providing insights that could inform therapeutic targets (Teixeira et al., 2024).


• Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea.: This study examines the effects of ENU on T lymphocyte clonality and trafficking in mice. The findings provide insights into the mutagenic and immunological impacts of ENU, contributing to our understanding of chemical-induced mutations (Judice et al., 2023).


• Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.: This proof-of-concept study integrates duplex sequencing technology to test genetic toxicity in rats exposed to ENU. The results demonstrate the feasibility and effectiveness of this approach in detecting mutagenic effects, highlighting its potential for genetic toxicity assessment (Smith-Roe et al., 2023).

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Packaging

Weight on dry basis.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H312 + H332,H350,H360
• Precautionary Statements: P202 - P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves